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DiscoverX PathHunter™ U2OS OX40 Signaling Assay

Product Code. 17364359
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17364359

Brand: DiscoverX 931080C3

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This item is not returnable. View return policy

Description

The PathHunter™ U2OS OX40 Signaling Assay measures OX40 signal by activation-induced stabilization of NIK. This cell line ships as two vials of cryopreserved cells.

The PathHunter OX40 Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of OX40 induced non-canonical NF-κB signaling via detection of NIK stabilization. This product uses EFC technology. The included cell line overexpresses ED-tagged NIK (NF-kappa-B Inducing Kinase) protein as well as untagged OX40 receptor. Upon activation of the receptor by its ligand or an antibody, NIK is stabilized, allowing detection of EFC signal when treated with exogenous EA. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry non-canonical NF-κB signaling via detection of NIK stabilization
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist OX40L
Quantity 2 Vials
Target Entry OX40
Accession Number NM_003327.3
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