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Description
Pax6 Monoclonal specifically detects Pax6 in Human, Mouse, Rat, Chicken samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Flow (Intracellular).
Specifications
| Pax6 | |
| Monoclonal | |
| DyLight 755 | |
| keratitis), MGC17209, Oculorhombin, paired box 6, paired box protein Pax-6 | |
| Mouse | |
| 47 kDa | |
| 0.1 mL | |
| Cellular Markers, Diabetes Research, Neuronal Stem Cell Markers, Neuroscience, Sensory Systems, Stem Cell Markers, Stem Cells, Transcription Factors and Regulators, Vision | |
| 5080 | |
| Human, Mouse, Rat, Chicken | |
| Purified |
| Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen) | |
| PAX6/498 | |
| Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen | |
| PAX6 | |
| Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein | |
| Protein A or G purified | |
| RUO | |
| Primary | |
| Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain. | |
| Store at 4C in the dark. | |
| IgG1 κ |
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