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Invitrogen™ Paxillin Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5120618
This item is not returnable.
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Description
Positive test controls include: PC-3. The target is usually found in the following locations: Cell junction, Cytoplasm, cell cortex, cytoskeleton, focal adhesion. Immunogen sequence: MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP.
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
Specifications
| Paxillin | |
| Polyclonal | |
| Unconjugated | |
| PXN | |
| adaptor protein; AW108311; AW123232; FLJ16691; hCG_1778014; I79_001229; myocardial ischemic preconditioning associated protein 7; Pax; PAX-1; PAXI; Paxillin; paxillin a; paxillin alpha; pxn; pxna; testicular tissue protein Li 134; TGFB1I1; transforming growth factor beta 1 induced transcript 1; wu:fw71f12 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 19303, 5829 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot | |
| 1.09 mg/mL | |
| PBS with 50% glycerol and 0.01% thimerosal; pH 7.3 | |
| P49023, Q8VI36 | |
| PXN | |
| A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Paxillin (NP_002850.2). | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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