Invitrogen™ PBRM1 Polyclonal Antibody

Description

Immunogen sequence: KMEEYDDVNL LTADFQLLFN NAKSYYKPDS PEYKAACKLW DLYLRTRNEF VQKGEADDED DDEDGQDNQG TVTEGSSPAY LKEILEQLLE AIVVATNPSG RLISELFQKL PSKVQYPDYY AIIKEPIDLK TIAQRIQNGS YKSIHA Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 97%.

The PBRM1 gene encodes a subunit of the PBAF (Polybromo-associated BAF) chromatin remodeling complex, playing a crucial role in the regulation of chromatin structure and transcription. PBRM1, also known as BAF180, contains bromodomains that recognize acetylated lysine residues on histone tails, facilitating chromatin remodeling necessary for effective transcriptional regulation. This gene is frequently mutated in renal cell carcinoma, particularly clear cell renal cell carcinoma (ccRCC), where such mutations are implicated in the pathogenesis of the disease. PBRM1 acts as a tumor suppressor, and its loss of function can lead to deregulation of gene expression, contributing to oncogenic processes. It is involved in pathways that govern cell cycle regulation and DNA damage response, reflecting its importance in maintaining genomic stability. Ongoing research focuses on understanding PBRM1's interactions within chromatin remodeling complexes and its potential as a therapeutic target in cancer treatment.