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Invitrogen™ PCNA Monoclonal Antibody (PC10), Biotin
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Product Code. 11324433
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Quantity:
500 μL
Unit Size:
500µL
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Product Code. Quantity unitSize
11324433 500 μL 500µL
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Product Code. 11324433 Supplier Invitrogen™ Supplier No. MA511355

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Description

Mouse Monoclonal Antibody

Methanol fixation is required for immunofluorescence and flow cytometry staining. To decrease nonspecific staining for both applications, using a Biotin/Streptavidin blocker is recommended. By WB, MA5-11355 detects a predominant band between 30-35kD, and fainter nonspecific bands at ~72kD and 130kD.

PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e. relevant to prognosis). PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PCNA
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone PC10
Concentration 200 μg/mL
Conjugate Biotin
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Pcna
Gene Accession No. P04961, P12004
Gene Alias ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; hypothetical protein LOC515499; MGC8367; Pcna; pcna protein; Pcna/cyclin; PCNAR; POL30; Proliferating cell nuclear antigen; wu:fa28e03; wu:fb36g03; YBR0811; YBR088C
Gene Symbols Pcna
Host Species Mouse
Immunogen Recombinant rat PCNA protein.
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25737, 5111
Target Species Human, Rat, Non-human Primate, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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