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PD-L1 Monoclonal Antibody (OTI1B12), TrueMAB™, OriGene

Product Code. 17566852
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100 μL
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17566852 100 μL 100µL
17586852 30 μL 30µL
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Product Code. 17566852 Supplier Origene Technologies Supplier No. TA507086

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Description

Mouse Monoclonal Antibody

PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.

Specifications

Antigen PD-L1
Applications Western Blot
Classification Monoclonal
Clone OTI1B12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene CD274
Gene Accession No. Q9NZQ7
Gene Alias B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
Gene Symbols CD274
Host Species Mouse
Immunogen Full length human recombit protein of human CD274 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29126
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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