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PD-L1 Mouse anti-Human, Clone: UMAB229, liquid, UltraMAB™
Mouse Monoclonal Antibody
Brand: Origene Technologies UM870121
This item is not returnable.
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Description
PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.Specifications
| PD-L1 | |
| Monoclonal | |
| Unconjugated | |
| CD274 | |
| B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 29126 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| UMAB229 | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9NZQ7 | |
| CD274 | |
| Human recombit protein fragment corresponding to amino acids 19-290 of human CD274 produced in E.coli. | |
| 30 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
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