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Invitrogen™ PDE12 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA560267

Product Code. 15758101

  • € 546.00 / 100µL

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Description

Description

Immunogen sequence: CGDFNSTPST GMYHFVINGS IPEDHEDWAS NGEEERCNMS LTHFFKLKSA CGEPAYTNYV GGFHGCLDYI FIDLNALEVE QVIPLPSHEE VTT Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 97%.

PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PDE12
Polyclonal
Unconjugated
PDE12
2',5'-phosphodiesterase 12; 2',5'-phosphodiesterase 12-like protein; 2'-PDE; 2-PDE; 2'-phosphodiesterase; E430028B21Rik; fc58c05; fi42f03; LOC558284 protein; LOW QUALITY PROTEIN: 2',5'-phosphodiesterase 12; LRRGT00074; Mitochondrial deadenylase; PDE12; phosphodiesterase 12; RGD1310975; wu:fc58c05; wu:fi42f03; zgc:136374
Rabbit
Antigen affinity chromatography
RUO
201626
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.05 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q6L8Q7
PDE12
Recombinant protein corresponding to Human PDE12. Recombinant protein control fragment (Product #RP-100240).
100 μL
Primary
Human
Antibody
IgG
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