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Invitrogen™ PDE8B Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA583361
This item is not returnable.
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Description
Immunogen sequence: FVSLKKLCCT TDNNKQIHKI HRDSGDNSQT EPHSFRYKNR RKESIDVKSI SSRGSDAPSL QNRRYPS Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 93%.
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.
Specifications
| PDE8B | |
| Polyclonal | |
| Unconjugated | |
| PDE8B | |
| 3',5' cyclic nucleotide phosphodiesterase 8B; ADSD; B230331L10Rik; C030047E14Rik; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; cell proliferation-inducing gene 22 protein; FLJ11212; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; hsPDE8B; Pde8b; phosphodiesterase 8B; PIG22; PPNAD3; RNPDE8B | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 8622 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| O95263 | |
| PDE8B | |
| Recombinant protein corresponding to Human PDE8B. Recombinant protein control fragment (Product #RP-96876). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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