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Invitrogen™ PDHA1 Monoclonal Antibody (S.975.6)
Rabbit Monoclonal Antibody
Brand: Invitrogen™ MA514805
This item is not returnable.
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Description
It is not recommended to aliquot this antibody.
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications
| PDHA1 | |
| Monoclonal | |
| 15 μg/mL | |
| 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5 | |
| P08559, P26284, P35486 | |
| PDHA1 | |
| Synthetic peptide corresponding to the sequence of human pyruvate dehydrogenase. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Monkey, Rat | |
| Antibody | |
| IgG |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| S.975.6 | |
| Unconjugated | |
| PDHA1 | |
| PDHA; PDHA1; Pdha-1; PDHAD; PDHCE1A; PDHE1-A type I; PHE1A; pyruvate dehydrogenase; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase complex, E1-alpha polypeptide 1; pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component alpha subunit; pyruvate dehydrogenase E1 component alpha subunit precursor; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1 subunit; pyruvate dehydrogenase E1 subunit alpha 1; pyruvate dehydrogenase E1alpha subunit | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 18597, 29554, 5160 | |
| -20°C | |
| Liquid |
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