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  6. Invitrogen™ PDK1 Recombinant Rabbit Monoclonal Antibody (5T6S8)

Invitrogen™ PDK1 Recombinant Rabbit Monoclonal Antibody (5T6S8)

Product Code. 31905245
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100 μL
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100µL
20µL
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31905245 20 μL 20µL
17156393 100 μL 100µL
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Product Code. 31905245 Supplier Invitrogen™ Supplier No. MA569827

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: STAPRPRVET SRAVPLAGFG YGLPISRLYA QYFQGDLKLY SLEGYGTDAV IYIKALSTDS IERLPVYNKA AWKHYNTNHE ADDWCVPSRE PKDMTTFRSA.

PDK1 (pyruvate dehydrogenase kinase, isozyme 1) gene, located on chromosome 2q31.1, encodes a member of the pyruvate dehydrogenase kinase family. This kinase plays a crucial role in the regulation of glucose metabolism by phosphorylating and inactivating the pyruvate dehydrogenase complex (PDC), which converts pyruvate to acetyl-CoA, linking glycolysis to the Krebs cycle. Structurally, the PDK1 protein contains a kinase domain that is essential for its enzymatic activity. PDK1 acts as a gatekeeper of glucose oxidation and is tightly regulated by various metabolic signals, including insulin and hypoxia. Dysregulation of PDK1 activity has been implicated in metabolic disorders such as diabetes and cancer, where it contributes to altered cellular energy homeostasis and metabolic reprogramming.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PDK1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 5T6S8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.05% BSA and 0.05% ProClin 300; pH 7.3
Gene PDK1
Gene Accession No. Q15118, Q63065, Q8BFP9
Gene Alias [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; B830012B01; D530020C15Rik; isoenzyme 1; kinase isoenzyme 1; lipoamide; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; PDH kinase 1; PDHK1; PDK p48; Pdk1; pyruvate dehydrogenase; pyruvate dehydrogenase kinase 1; Pyruvate dehydrogenase kinase isoform 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1
Gene Symbols PDK1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 337-436 of human PDK1/PDHK1 (NP_0026011)
Purification Method Affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116551, 228026, 5163
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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