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Invitrogen™ PDXK Monoclonal Antibody (OTI5H5)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA525565
This item is not returnable.
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Description
PDXK Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow
Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in the intermediate metabolism of amino acids and neurotransmitters. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA reveals pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript is expressed in all tissues tested. The expression of PDXK shows circadian oscillations. The expression of Pdxk in mouse liver and brain is regulated by the 3 PAR bZIP transcription factors, Dbp, Hlf, and Tef, which also show circadian oscillations in expression. Mice devoid of all 3 transcription factors show decreased levels of brain PLP, serotonin, and dopamine, and are highly susceptible to frequently lethal generalized spontaneous and audiogenic epilepsies.
Specifications
| PDXK | |
| Monoclonal | |
| 0.82 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O00764 | |
| PDXK | |
| Full length human recombinant protein of PDXK produced in HEK293 cell. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| OTI5H5 | |
| Unconjugated | |
| PDXK | |
| 2310036D04Rik; AA119688; C21orf124; C21orf97; C77999; epididymis secretory sperm binding protein Li 1a; HEL-S-1a; Pdxk; Pkh; PNK; PRED79; pyridoxal (pyridoxine, vitamin B6) kinase; pyridoxal kinase; pyridoxamine kinase; pyridoxine kinase; vitamin B6 kinase | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 8566 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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