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Invitrogen™ PEN2 Polyclonal Antibody

Product Code. 11578801
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Quantity:
100 μL
Unit Size:
100µL
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11578801 100 μL 100µL
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Product Code. 11578801 Supplier Invitrogen™ Supplier No. PA316762

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Description

Rabbit Polyclonal Antibody

This antibody has primarily been tested in HA-PEN2 transfected cells combining Immunoprecipitation with Western blot analysis (ECL). For endogenous sample testing, it is suggested that the investigator load a greater amount of protein on the gel. Suggested positive control: antigen standard for PSENEN (transient overexpression lysate).

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PEN2
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum with 0.05% sodium azide
Gene PSENEN
Gene Accession No. Q9CQR7, Q9NZ42
Gene Alias 1700023M09Rik; gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; liver regeneration-related protein LRRGT00140; LRRGT00140 mRNA; MDS033; MSTP064; Pen2; Pen-2; presenilin enhancer 2; presenilin enhancer 2 homolog; presenilin enhancer 2 homolog (C. elegans); presenilin enhancer gamma secretase subunit; presenilin enhancer gamma-secretase subunit; presenilin enhancer protein 2; presenilin enhancer, gamma-secretase subunit; Psenen; RGD1312037
Gene Symbols PSENEN
Host Species Rabbit
Immunogen A synthetic peptide corresponding to the C-terminus of human PEN2 (within residues 50-101).
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55851, 66340
Target Species Human, Mouse
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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