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  5. Tocris Bioscience™ Pexidartinib

Tocris Bioscience™ Pexidartinib

Product Code. 18717136
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18717136 10 mg 10mg
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Product Code. 18717136 Supplier Tocris Bioscience™ Supplier No. 7590/10

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145.40 EUR valid until 2026-03-31
BEST PRICE on Promo! Use promo code "27931" to get your promotional price.
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Description

Potent CSF-1R inhibitor

Pexidartinib is a potent colony-stimulating factor-1 receptor (CSF-1R) tyrosine kinase inhibitor (IC50 = 20 nM). In the B16F10 mouse melanoma model, Pexidartinib reduces the systemic and local accumulation of macrophages without affecting Gr-1+ myeloid derived suppressor cells. When combined with tumor-specific CD8 T cell immunotherapy, Pexidartinib promotes the control of tumor growth. In the BRAFV600E-driven mouse melanoma model, Pexidartinib improves the efficacy of adoptive cell therapy with reduction of TIMs and an increase in tumor-infiltrating lymphocytes and T cells. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
CAS 1029044-16-3
Quantity 10 mg
Target Additional RTK Inhibitors
Molecular Formula C20H15ClF3N5
Purity 98%
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