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Tocris Bioscience™ PF 06409577
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Product Code. 18756559
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18756559

Brand: Tocris Bioscience™ 6114/50

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Description

Potent and selective allosteric activator of AMPK

PF 06409577 is a potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Exhibits minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Improves kidney function and reduces proteinuria in a preclinical model of diabetic nephropathy. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material PF 06409577
CAS 1467057-23-3
Synonym 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
Quantity 50 mg
Solubility Soluble to 100mM in DMSO and to 20mM in ethanol
Molecular Formula C19H16ClNO3
Formula Weight 341.79
Physical Form Solid
Color Gray
Product Type Bioactive Small Molecule
Purity 99%
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For Research Use Only.

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