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PF-5274857, MedChemExpress

Product Code. 16498387
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Product Code. 16498387 Supplier Medchem Express Supplier No. HY13459

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Description

MedChemExpress PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.

PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.

Specifications

Chemical Name or Material PF-5274857
CAS 1373615-35-0
Color Yellow
Purity Grade Notes Research
Molecular Formula C20H25ClN4O3S
Quantity 5 mg
Solubility Information DMSO : 125 mg/mL (286.07 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O
Molecular Weight (g/mol) 436.96
Formula Weight 436.96
Percent Purity 98.89%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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