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Invitrogen™ PHAP Polyclonal Antibody

Product Code. 11545833
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Quantity:
50 μg
Unit Size:
50µg
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11545833 50 μg 50µg
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Product Code. 11545833 Supplier Invitrogen™ Supplier No. PA128342

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Raji cell lysate.

Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHAP
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide; pH 7.4
Gene ANP32A
Gene Accession No. O35381, P39687, P49911, P97822, Q5XIE0, Q92688, Q9BTT0, Q9EST5, Q9EST6
Gene Alias 2410015B15Rik; 2810018A15Rik; Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic (leucine-rich) nuclear phosphoprotein 32 family, member D; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic leucine-rich nuclear phosphoprotein 32 family member B; acidic leucine-rich nuclear phosphoprotein 32 family member E; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein 32 family member A; acidic nuclear phosphoprotein 32 family member B; acidic nuclear phosphoprotein 32 family member E; acidic nuclear phosphoprotein 32 family, member A; acidic nuclear phosphoprotein 32 family, member B; acidic nuclear phosphoprotein pp32; Acidic protein rich in leucines; AI047746; AI326868; Anp32; Anp32a; Anp32b; ANP32D; ANP32E; APRIL; C15orf1; cerebellar leucine rich acidic nuclear protein; cerebellar postnatal development protein 1; Cpd1; hepatopoietin Cn; HPPCn; hypothetical protein LOC509685; I1PP2A; inhibitor-1 of protein phosphatase-2A; LANP; LANPL; LANP-L; LANP-like protein; Leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein LANP; leucine-rich acidic nuclear protein like; MAPM; Mapmodulin; mLANP-L; Pal31; PHAP1; PHAPI; PHAPI2; PHAPI2a; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; PP32; proliferation related acidic leucine rich protein PAL31; proliferation-related acidic leucine-rich protein PAL31; Putative HLA-DR-associated protein I; putative HLA-DR-associated protein I-2; putative human HLA class II associated protein I; silver-stainable protein SSP29; SSP29; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A; W91701
Gene Symbols ANP32A, ANP32B, ANP32E
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids near the amino terminus of human PHAP (accession no. P39687).
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10541, 11737, 170724, 25379, 361999, 66471, 67628, 8125, 81611
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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