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Invitrogen™ Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody (RC6F8)
Mouse Monoclonal Antibody
Brand: Invitrogen™ A21328
This item is not returnable.
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Description
Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody for ICC/IF
Phosphatidylinositol (3, 4, 5)-trisphosphate (PtdIns(3, 4, 5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol (4, 5)-bisphosphate. PtdIns (3, 4, 5) P3 is dephophosphorylated by the phosphatase, PTEN on the 3 position and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring. The PH domain in a number of proteins binds to PtdIns (3, 4, 5) P3. Such proteins include Akt/PKB, PDK1, Btk1 and ARNO. The generation of PtdIns (3, 4, 5) P3 at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins to translocate to the plasma membrane and accordingly affects their activity. The PH domain allows binding between PtdIns (3, 4, 5) P3 and G-protein coupled receptor kinases (GRKs). This enhances the binding of the GRK to the plasma membrane. [National Center for Biotechnology Information. PubChem Compound Database; CID=53477782].
Specifications
| Phosphatidylinositol 3,4,5-trisphosphate | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.1% BSA and 5mM sodium azide; pH 7.2 | |
| Mouse | |
| Purified | |
| RUO | |
| Chemical | |
| Antibody | |
| IgM |
| Immunocytochemistry | |
| RC6F8 | |
| Unconjugated | |
| C12H24O22P4; phosphatidylinositol 3; phosphatidylinositol-3; PIP3 | |
| phosphatidylinositol 3,4,5-diphosphate. | |
| 100 μL | |
| Primary | |
| 4°C | |
| Liquid | |
| Chemical |
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