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Invitrogen™ Phospho-Aconitase 1 (Ser711) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA540262
This item is not returnable.
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Description
This antibody is predicted to react with mouse, rat, and monkey based on sequence homology.
Aconitase 1 (ACO1) also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Specifications
| Phospho-Aconitase 1 (Ser711) | |
| Polyclonal | |
| Unconjugated | |
| ACO1 | |
| ACO1; Aco-1; Acon1; Aconitase; aconitase 1; aconitase 1, soluble; aconitate hydratase, cytoplasmic; ACONS; AH; Citrate hydro-lyase; cytoplasmic aconitase; cytoplasmic aconitate hydratase; cytosplasmic aconitase; epididymis luminal protein 60; ferritin repressor protein; FRP; HEL60; Ireb1; Irebp; IRE-BP 1; IREBP1; iron regulatory protein 1; iron-responsive element binding protein 1; iron-responsive element-binding protein 1; IRP1; OTTHUMP00000021176; OTTHUMP00000021177; OTTHUMP00000045233; soluble aconitase | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 11428, 48, 50655 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Immunohistochemistry, Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide; pH 7.4 | |
| P21399, P28271, Q63270 | |
| ACO1 | |
| Synthesized peptide derived from human IRP-1 around the phosphorylation site of S711. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Monkey, Rat | |
| Antibody | |
| IgG |
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