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Invitrogen™ Phospho-beta Catenin/gamma Catenin (Tyr333, Tyr324) Polyclonal Antibody
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Product Code. 17896948
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Quantity:
100 μL
Unit Size:
100µL
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17896948 100 μL 100µL
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Product Code. 17896948 Supplier Invitrogen™ Supplier No. PA5143665

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Description

Rabbit Polyclonal Antibody

The antibody detects a 92kDa* protein corresponding to the molecular mass of beta-Catenin on SDS-PAGE immunoblots of human A431 cells treated with pervanadate, but not in control cells. In addition, the pervanadate induced reactivity is not observed after alkaline phosphatase treatment.

beta-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions. Deletions in the cytoplasmic domain of E-Cadherin eliminate catenin binding and result in a loss of cell adhesion. Tyrosine phosphorylation of beta-Catenin can regulate its interaction with critical components of adherens junctions. Both Fer and Fyn kinases phosphorylate tyrosine 142 in vitro. Overexpression of these kinases in epithelial cells disrupts interactions between alpha- and beta-Catenins. The phosphorylation of tyrosine 142 may act as a switch from the transcriptional to the adhesive role of beta-Catenin. Src family kinases can also phosphorylate tyrosine 86 and 654 in beta-Catenin. The Tyr-654 phosphorylation regulates beta-Catenin binding to E-cadherin. Thus, site-specific tyrosine phosphorylation of beta-Catenin may regulate protein-protein interactions leading to changes in cell adhesion.
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Specifications

Antigen Phospho-beta Catenin/gamma Catenin (Tyr333, Tyr324)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene CTNNB1
Gene Accession No. P35222, Q02248, Q9WU82
Gene Alias Catenin beta1; CTNNB1
Gene Symbols CTNNB1
Host Species Rabbit
Immunogen Phospho-beta-Catenin (Tyr-333) synthetic peptide (coupled to KLH) that includes amino acid residues around tyrosine 333 of human beta-Catenin. This peptide sequence is highly conserved in rat and mouse beta-Catenin, and has high homology to the conserved site in gamma-Catenin (Tyr-324).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12387, 1499, 84353
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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