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Invitrogen™ Phospho-Btk (Tyr223, Tyr225) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5105619
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Description
Antibody detects endogenous levels of BTK only when phosphorylated at Tyr223/225.
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.
Specifications
| Phospho-Btk (Tyr223, Tyr225) | |
| Polyclonal | |
| Unconjugated | |
| BTK | |
| agammaglobulinaemia tyrosine kinase; agammaglobulinemia tyrosine kinase; AGMX1; AI528679; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; PSCTK1; RP1-164F3.2; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); xid; XLA; X-linked immune deficiency | |
| Rabbit | |
| Sequential Chromatography | |
| RUO | |
| 12229, 367901, 695 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P35991, Q06187 | |
| BTK | |
| A synthesized peptide derived from human BTK(Accession Q06187), corresponding to amino acid residues around phosphorylated Tyr223. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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