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  6. Invitrogen™ Phospho-c-Cbl (Ser669) Recombinant Rabbit Monoclonal Antibody (K01_1N99)

Invitrogen™ Phospho-c-Cbl (Ser669) Recombinant Rabbit Monoclonal Antibody (K01_1N99)
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Product Code. p-200114201
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30825390 100 μL
30825145 50 μL
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Product Code. 30825390 Supplier Invitrogen™ Supplier No. MA563285

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Description

Rabbit Recombinant Monoclonal Antibody

Phospho-c-Cbl (Ser669) Recombinant Monoclonal Antibody for Western Blot

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
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Specifications

Antigen Phospho-c-Cbl (Ser669)
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1N99
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 150mM NaCl, 40% glycerol, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene Cbl
Gene Accession No. P22681
Gene Alias 4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
Gene Symbols Cbl
Host Species Rabbit
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser669 of human CBL.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 867
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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