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Invitrogen™ Phospho-Cdc20 (Thr70) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5105704
This item is not returnable.
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Description
Antibody detects endogenous levels of CDC20 only when phosphorylated at Thr70.
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Specifications
| Phospho-Cdc20 (Thr70) | |
| Polyclonal | |
| Unconjugated | |
| CDC20 | |
| 2310042N09Rik; bA276H19.3; C87100; cdc20; CDC20 cell division cycle 20 homolog; cdc20.S; CDC20A; cell cycle protein p55CDC; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 S homeolog; cell division cycle protein 20 homolog; fizzy1; mmCdc20; p55cdc; XELAEV_18025163mg; X-FZY | |
| Rabbit | |
| Sequential Chromatography | |
| RUO | |
| 107995, 64515, 991 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q12834, Q62623, Q9JJ66 | |
| CDC20 | |
| A synthesized peptide derived from human CDC20(Accession Q12834), corresponding to amino acid residues around phosphorylated Thr70. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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