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Phospho-Cdc25C (Thr48) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538358
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Description
Cyclin-dependent kinases are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin-dependent kinases is also regulated by the phosphorylation status, which is controlled by the antagonistic action of Wee1 kinase and CDC25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, and CDC25C. These three genes function at different phases of the cell cycle. Whereas CDC25A and CDC25B are expressed throughout the cell cycle, with peak expression in G1 for CDC25A and in both G1-S-phase and G2 for CDC25B, CDC25C is predomitly expressed in G2.
Specifications
| Phospho-Cdc25C (Thr48) | |
| Polyclonal | |
| Unconjugated | |
| CDC25C | |
| CDC25M1, Dual specificity phosphatase Cdc25C, EC 3.1.3.48, M-phase inducer phosphatase 3, MPIP3 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 12532, 995 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P30307, P48967 | |
| CDC25C | |
| A synthetic phosphopeptide derived from human CDC25C around the phosphorylation site of Thr48 (P-R-TP-P-V) | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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