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Invitrogen™ Phospho-DOK1 (Tyr398) Polyclonal Antibody

Product Code. 15544491
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Quantity:
100 μL
Unit Size:
100µL
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15544491 100 μL 100µL
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Product Code. 15544491 Supplier Invitrogen™ Supplier No. PA537549

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Description

Rabbit Polyclonal Antibody

A suggested positive control for Western blot is K562 cells; suggested positive control for IHC is human breast carcinoma.

DOK1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-DOK1 (Tyr398)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DOK1
Gene Accession No. Q99704
Gene Alias AW557123; Docking protein 1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); Dok; DOK 1; DOK1; Dok-1; Downstream of tyrosine kinase 1; downstream of tyrosine kinase-1; MGC117395; MGC138860; p240; p62 dok; p62(dok); p62DOK; pp62; TLP1; TP1; TROVE domain family; TROVE1; VAULT2
Gene Symbols DOK1
Host Species Rabbit
Immunogen Peptide sequence around phosphorylation site of tyrosine 398 (E-G-Y(p)-E-L) derived from Human p62Dok.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1796
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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