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Invitrogen™ Phospho-EGFR (Ser1046, Ser1047) Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA577953

Product Code. 16336664

  • € 566.00 / 100µL

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Description

Description

Positive Control: EGF treated A431 cell Predicted Reactivity: Pig (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-EGFR (Ser1046, Ser1047)
Polyclonal
Unconjugated
EGFR
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Rabbit
Antigen affinity chromatography
RUO
1956
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1.9 mg/mL
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
P00533
EGFR
Carrier-protein conjugated synthetic peptide surrounding phospho Ser1046/Ser1047 of human EGFR. The exact sequence is proprietary.
100 μL
Primary
Human
Antibody
IgG
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