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Invitrogen™ Phospho-FOXO1/FOXO3/FOXO4 (Thr24, Thr32) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA536737
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Description
This antibody detects endogenous protein at a molecular weight of 70-82 kDa. Purity is >95% by SDS-PAGE.
FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
Specifications
| Phospho-FOXO1/FOXO3/FOXO4 (Thr24, Thr32) | |
| Polyclonal | |
| Unconjugated | |
| FOXO3 | |
| 1110048B16Rik; 2010203A17Rik; AF6q21; AF6q21 protein; AFX; AFX1; Afxh; AI876417; C76856; FKH1; FKHR; Fkhr1; Fkhr2; Fkhr3; FKHRL1; FKHRL1P2; fork head domain transcription factor AFX1; forkhead box O1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box O3; forkhead box O3A; forkhead box O4; forkhead box protein O1; Forkhead box protein O1A; forkhead box protein O3; Forkhead box protein O4; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma-like 1; forkhead protein; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; Foxo1; FOXO1A; FOXO2; FOXO3; Foxo3a; FOXO4; MGC120490; Mllt7; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; RGD1561201 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 2308, 2309, 4303 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
| O43524, P98177, Q12778 | |
| FOXO1, FOXO3, FOXO4 | |
| Synthetic phosphopeptide derived from human FoxO1 around the phosphorylation site of Threonine 24. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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