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Invitrogen™ Phospho-GAB1 (Tyr627) Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ 44568G

Product Code. 10241853

  • € 506.00 / 100µL

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Description

Description

Phospho-GAB1 (Tyr627) Polyclonal Antibody for Western Blot

Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet-derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met), and epidermal growth factor receptor (EGF), as well as in response to cell-cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3-kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-GAB1 (Tyr627)
Polyclonal
Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
Q13480, Q9QYY0
GAB1
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Gab1 that contains tyrosine 627. The sequence is conserved in mouse.
100 μL
Primary
Human, Mouse
Antibody
IgG
Western Blot
Unconjugated
GAB1
AA408973; AW107238; EGK_16125; GAB1; GRB2 associated binding protein 1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated binding protein 1 long isoform; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1; OTTHUMP00000220263
Rabbit
Antigen Affinity Chromatography
RUO
14388, 2549
-20°C
Liquid
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