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Invitrogen™ Phospho-Girdin (Tyr1764) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5143704
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Description
The antibody was cross-absorbed to unphosphorylated Girdin (Tyr-1764) peptide before affinity purification using phospho-Girdin (Tyr-1764) peptide. This antibody detects a 250 kDa* protein on SDS-PAGE immunoblots of human A431 cells stimulated with EGF and Pervanadate. These reactivities are not observed after alkaline phosphatase treatment to dephosphorylate Girdin.
Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
Specifications
| Phospho-Girdin (Tyr1764) | |
| Polyclonal | |
| Unconjugated | |
| CCDC88A | |
| A430106J12Rik; AI848406; Akt phosphorylation enhancer; AKT-phosphorylation enhancer; Ape; C130096N06Rik; C330012F17Rik; Ccdc88a; coiled coil domain containing 88A; coiled-coil domain containing 88A; coiled-coil domain-containing protein 88A; D130005J21Rik; G alpha-interacting vesicle-associated protein; Galpha-interacting vesicle-associated protein; girders of actin filament; girders of actin filaments; girdin; GIV; Grdn; HkRP1; Hook-related protein 1; KIAA1212; RGD1306694 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 108686, 305605, 55704 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 0.25 mg/mL | |
| PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide | |
| Q3V6T2, Q5SNZ0 | |
| CCDC88A | |
| Phospho-Girdin (Tyr-1764) synthetic peptide (coupled to carrier) corresponding to amino acid residues around tyrosine 1764 in human Girdin. This sequence has high homology to rat and mouse Girdin, and the site is not conserved in other Girdin family members. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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