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Invitrogen™ Phospho-INSR (Tyr1361) Polyclonal Antibody
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Product Code. 16621205
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Quantity:
100 μL
Unit Size:
100µL
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16621205 100 μL 100µL
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Product Code. 16621205 Supplier Invitrogen™ Supplier No. PA5104754

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of IR only when phosphorylated at Tyrosine 1361.

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
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Specifications

Antigen Phospho-INSR (Tyr1361)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene INSR
Gene Accession No. P06213, P15127, P15208
Gene Alias 4932439J01Rik; CD 220; CD220; CD220 antigen; CD220 beta; CD221; D630014A15Rik; HHF 5; HHF5; IGF-I receptor; INSR; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR 1; IR beta; IR1; IR-1; IR-A; IR-B
Gene Symbols INSR
Host Species Rabbit
Immunogen A synthesized peptide derived from human INSR(Accession P06213), corresponding to amino acid residues around phosphorylated Tyr1361.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16337, 24954, 3643
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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