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Invitrogen™ Phospho-LAT (Tyr220) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5105124
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Description
Antibody detects endogenous levels of LAT only when phosphorylated at Tyr220, which site historically referenced as Tyr191.
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
Specifications
| Phospho-LAT (Tyr220) | |
| Polyclonal | |
| Unconjugated | |
| LAT | |
| 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; Lat; LAT1; linker for activation of T cells; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells; linker for activation of T-cells family member 1; linker protein; p36-38; pp36 | |
| Rabbit | |
| Sequential chromatography | |
| RUO | |
| 16797, 27040 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O43561, O54957 | |
| LAT | |
| A synthesized peptide derived from human LAT around the phosphorylation site of Tyr191. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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