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Invitrogen™ Phospho-LATS2 (Ser380) Polyclonal Antibody
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Product Code. 16634515
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Quantity:
100 μL
Unit Size:
100µL
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16634515 100 μL 100µL
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Product Code. 16634515 Supplier Invitrogen™ Supplier No. PA5105697

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of LATS2 only when phosphorylated at Ser380.

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction. LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity. LATS2 plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-LATS2 (Ser380)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LATS2
Gene Accession No. Q7TSJ6, Q9NRM7
Gene Alias 4932411G09Rik; AV277261; AW228608; h-warts; Kinase phosphorylated during mitosis protein; KPM; large tumor suppressor 2; large tumor suppressor homolog 2; large tumor suppressor kinase 2; large tumor suppressor, homolog 2; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2; LATS2; serine/threonine kinase KPM; serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; si:ch211-173o4.2; Warts-like kinase
Gene Symbols LATS2
Host Species Rabbit
Immunogen A synthesized peptide derived from human LATS2(Accession Q9NRM7), corresponding to amino acid residues around phosphorylated Ser380.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26524, 50523
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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