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Invitrogen™ Phospho-LRP5 (Tyr1473) Polyclonal Antibody
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Product Code. 16631545
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Quantity:
100 μL
Unit Size:
100µL
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16631545 100 μL 100µL
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Product Code. 16631545 Supplier Invitrogen™ Supplier No. PA5105096

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of LRP5 only when phosphorylated at Tyr1473.

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-LRP5 (Tyr1473)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LRP5
Gene Accession No. O75197, Q91VN0
Gene Alias BMND1; EVR1; EVR4; HBM; HGNC:6697; LDL receptor related protein 5; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 7; LR3; Lrp5; LRP-5; LRP7; LRP-7; mKIAA4142; OPPG; OPS; OPTA1; VBCH2
Gene Symbols LRP5
Host Species Rabbit
Immunogen A synthesized peptide derived from human LRP5(Accession O75197), corresponding to amino acid residues around phosphorylated Tyr1473.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16973, 293649, 4041
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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