missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ Phospho-MEK3 (Thr222) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA537699
This item is not returnable.
View return policy
Description
A suggested positive control for Western blot is Jurkat cells; suggested positive control for IHC is human brain tissue.
MAP2K3 (MEK3) is a dual-specificity protein kinase which acts in cellular signal transduction pathways, and is necessary for the expression of glucose transporter. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for MEK3.
Specifications
| Phospho-MEK3 (Thr222) | |
| Polyclonal | |
| Unconjugated | |
| MAP2K3 | |
| AW212142; dual specificity mitogen-activated protein kinase kinase 3; EC 2.7.12.2; MAP kinase kinase 3; Map2k3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; Mek3; mitogen activated protein kinase kinase 3; mitogen-activated protein kinase kinase 3; Mkk3; mMKK3b; Prkmk3; protein kinase, mitogen-activated, kinase 3; SAPK kinase 2; SAPKK2; SAPKK-2; SKK2; Stress-activated protein kinase kinase 2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 5606 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P46734 | |
| MAP2K3 | |
| Peptide sequence around phosphorylation site of threonine 222(A-K-T(p)-M-D) derived from Human MAP2K3. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction