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Invitrogen™ Phospho-PAK3 (Ser154) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA599140
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Description
Antibody detects endogenous levels of PAK3 only when phosphorylated at Sersine 154.
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
Specifications
| Phospho-PAK3 (Ser154) | |
| Polyclonal | |
| Unconjugated | |
| PAK3 | |
| 2.7.11.1; adriamycin resistance-associated; ARA; beta-PAK; bPAK; CDC42/RAC effector kinase PAK-B; CDKN1A; hPAK3; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 3; p21 (RAC1) activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21-activated kinase 3; p65-PAK; PAK beta; Pak3; Pak-3; PAK3beta; Pak65alpha; Pak65beta; Pakb; Serine/threonine-protein kinase PAK 3; Stk4 | |
| Rabbit | |
| sequential chromatography | |
| RUO | |
| 18481, 29433, 5063 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O75914, Q61036, Q62829 | |
| PAK3 | |
| A synthesized peptide derived from human PAK3(Accession O75914), corresponding to amino acid residues around phosphorylated Ser154. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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