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Invitrogen™ Phospho-PAK5/PAK6 (Ser602, Ser560) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA537827
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Description
A suggested positive control for Western blot is HeLa cells.
PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction.PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
Specifications
| Phospho-PAK5/PAK6 (Ser602, Ser560) | |
| Polyclonal | |
| Unconjugated | |
| PAK5 | |
| 2900083L08Rik; 4732456M09; 6430627N20; KIAA1142; KIAA1264; p21 (CDKN1A)-activated kinase 6; p21 (CDKN1A)-activated kinase 7; p21 (RAC1) activated kinase 5; p21 (RAC1) activated kinase 6; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 6; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 6; p21(CDKN1A)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 6; p21-activated kinase 7; p21CDKN1A-activated kinase 7; PAK4; PAK-4; PAK5; PAK-5; Pak6; PAK-6; Pak7; PAK-7; protein kinase PAK5; Serine/threonine-protein kinase PAK 5; Serine/threonine-protein kinase PAK 6; serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 214230, 241656, 56924, 57144 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q3ULB5, Q8C015, Q9NQU5, Q9P286 | |
| PAK5, PAK6, Pak7 | |
| Peptide sequence around phosphorylation site of Serine 602/560(R-K-S(p)-L-V) derived from Human PAK5/6. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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