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  6. Invitrogen™ Phospho-PDPK1 (Ser241) Recombinant Rabbit Monoclonal Antibody (PDK1S241-F7), FITC, Invitrogen™

Invitrogen™ Phospho-PDPK1 (Ser241) Recombinant Rabbit Monoclonal Antibody (PDK1S241-F7), FITC, Invitrogen™

Product Code. 17156928 Shop All Thermo Scientific Products
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Product Code. 17156928 Supplier Invitrogen™ Supplier No. MA537339

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Description

Rabbit Recombinant Monoclonal Antibody

PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PDPK1 (Ser241)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone PDK1S241-F7
Conjugate FITC
Formulation PBS with 0.20% BSA and 0.09% sodium azide
Gene Pdpk1
Gene Accession No. O15530
Gene Alias 3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase
Gene Symbols Pdpk1
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Ser241 of human phospho PDPK1.
Purification Method Protein A/G
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5170
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG κ
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