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Invitrogen™ Phospho-PDPK1 (Tyr376) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA564559
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Description
Phospho-PDPK1 (Tyr376) Polyclonal Antibody detects endogenous levels of PDPK1 only when phosphorylated at Tyr376.
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Specifications
| Phospho-PDPK1 (Tyr376) | |
| Polyclonal | |
| Unconjugated | |
| Pdpk1 | |
| 3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 18607, 5170, 81745 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O15530, O55173, Q9Z2A0 | |
| Pdpk1 | |
| A synthesized peptide derived from human PDK1 (Phospho-Tyr376). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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