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Invitrogen™ Phospho-PDX1 (Ser66) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5118709
This item is not returnable.
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Description
Antibody detects endogenous levels of PDX1 only when phosphorylated at Ser66.
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Specifications
| Phospho-PDX1 (Ser66) | |
| Polyclonal | |
| Unconjugated | |
| PDX1 | |
| DLDBP; E3BP; Glucose-sensitive factor; GSF; Idx1; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; insulin promotor factor 1; insulin upstream factor 1; Ipf1; IPF-1; Islet/duodenum homeobox 1; islet/duodenum homeobox-1; IUF1; IUF-1; MODY4; PAGEN1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox 1; pancreatic and duodenal homeobox gene 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX1; pdx-1; somatostatin transactivating factor 1; somatostatin transcription factor 1; somatostatin-transactivating factor 1; Stf1; STF-1 | |
| Rabbit | |
| Sequential Chromatography | |
| RUO | |
| 18609, 29535, 3651 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P52945, P52946, P52947 | |
| PDX1 | |
| A synthesized peptide derived from human PDX1(Accession P52945), corresponding to amino acid residues around phosphorylated Ser66. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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