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Invitrogen™ Phospho-SIRT1 (Ser47) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA517391
This item is not returnable.
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Description
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other sirtuin proteins.
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
Specifications
| Phospho-SIRT1 (Ser47) | |
| Polyclonal | |
| Unconjugated | |
| SIRT1 | |
| 75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 23411 | |
| -20°C | |
| Liquid |
| Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 7.3 μg/mL | |
| 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
| Q96EB6 | |
| SIRT1 | |
| Synthetic phosphopeptide corresponding to residues surrounding pSer47 of human SirT1. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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