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Invitrogen™ Phospho-SLP76 (Tyr145) Polyclonal Antibody
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Product Code. 16570242
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Quantity:
100 μL
Unit Size:
100µL
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16570242 100 μL 100µL
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Product Code. 16570242 Supplier Invitrogen™ Supplier No. PA597411

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ADYEP; Positive Samples: U937; Cellular Location: Cytoplasm.

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SLP76 (Tyr145)
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.58 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene LCP2
Gene Accession No. Q13094, Q60787
Gene Alias 76 kDa tyrosine phosphoprotein; AI323664; BB161688; Lcp2; Lymphocyte cytosolic protein 2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD); SH2 domain-containing leukocyte protein of 76 kDa; SH2 domain-containing leukocyte protein of 76kD; SLP76; SLP-76; SLP-76 tyrosine phosphoprotein; twm
Gene Symbols LCP2
Host Species Rabbit
Immunogen A synthetic phosphorylated peptide around Y145 of human LCP2 (NP_0055561).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16822, 3937
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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