missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ Phospho-SLUG (Ser104) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5105047
This item is not returnable.
View return policy
Description
Antibody detects endogenous levels of SNAI2 only when phosphorylated at Ser104.
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
Specifications
| Phospho-SLUG (Ser104) | |
| Polyclonal | |
| Unconjugated | |
| SNAI2 | |
| MGC10182; neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; Slugh; SLUGH1; Snai2; snail family transcriptional repressor 2; snail family zinc finger 2; snail homolog 2; Snail2; snail-like protein 2; WS2D; Zinc finger protein SNAI2; zinc finger transcription factor snail 2 | |
| Rabbit | |
| sequential chromatography | |
| RUO | |
| 20583, 25554, 6591 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O08954, O43623, P97469 | |
| SNAI2 | |
| A synthesized peptide derived from human SNAI2(Accession O43623), corresponding to amino acid residues around phosphorylated Ser104. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat, Monkey | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction