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Invitrogen™ Phospho-TNFAIP3 (Ser381) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5114546
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Description
Antibody detects endogenous levels of A20/TNFAIP3 only when phosphorylated at Ser381.
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.
Specifications
| Phospho-TNFAIP3 (Ser381) | |
| Polyclonal | |
| Unconjugated | |
| TNFAIP3 | |
| A20; A20p37; A20p50; AISBL; OTU domain-containing protein 7C; OTUD7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha induced protein 3; TNF alpha-induced protein 3; TNFA1P2; TNFAIP3; TNFAIP3 (A20); Tnfip3; Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; zinc finger protein A20 | |
| Rabbit | |
| sequential chromatography | |
| RUO | |
| 683206, 7128 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide | |
| P21580 | |
| TNFAIP3 | |
| A synthesized peptide derived from human A20/TNFAIP3 around the phosphorylation site of Ser381. | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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