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Invitrogen™ Phospho-Trf2 (Thr188) Polyclonal Antibody
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Product Code. 16682375
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Quantity:
100 μL
Unit Size:
100µL
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16682375 100 μL 100µL
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Product Code. 16682375 Supplier Invitrogen™ Supplier No. PA5105937

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TRF2 only when phosphorylated at Thr188.

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Trf2 (Thr188)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TERF2
Gene Accession No. O35144, Q15554
Gene Alias Telomeric DNA-binding protein; telomeric repeat binding factor 2; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TERF2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
Gene Symbols TERF2
Host Species Rabbit
Immunogen A synthesized peptide derived from human TERF2(Accession Q15554), corresponding to amino acid residues around phosphorylated Thr188.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21750, 361403, 7014
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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