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Invitrogen™ Phospho-ULK1 (Ser758) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA578251
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Description
Positive Control: MCF7, MCF-7 (starvation for 16 hr, incubated in EBSS for 4 hr, and 200 nM Rapamycin treatment for 0.5 hr) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
Specifications
| Phospho-ULK1 (Ser758) | |
| Polyclonal | |
| Unconjugated | |
| ULK1 | |
| APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; ATG1A; AU041434; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; hATG1; KIAA0722; mKIAA0722; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; ULK 1; Ulk1; UNC 51; UNC51; unc-51 like autophagy activating kinase 1; unc-51 like kinase 1; Unc51.1; unc-51-like kinase 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 8408 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 0.3 mg/mL | |
| PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7 | |
| O75385 | |
| ULK1 | |
| Carrier-protein conjugated synthetic peptide surrounding phospho Ser758 of human ULK1. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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