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Invitrogen™ Phospho-VASP (Ser239) Polyclonal Antibody

Description
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with phosphorylated VASP homologues, such as Mena.
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
Specifications
Specifications
| Antigen | Phospho-VASP (Ser239) |
| Applications | Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Formulation | 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 |
| Gene | VASP |
| Gene Accession No. | P50552, P70460 |
| Gene Alias | Enah/Vasp-like; I79_012660; Unknown (protein for MGC:127789); vasodilator stimulated phosphoprotein; vasodilator-stimulated phosphoprotein; vasodilator-stimulated phosphoprotein (VASP); VASP |
| Gene Symbols | VASP |
| Host Species | Rabbit |
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