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Invitrogen™ Phospho-VAV1 (Tyr174) Polyclonal Antibody
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Product Code. 16326924
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Quantity:
100 μL
Unit Size:
100µL
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16326924 100 μL 100µL
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Product Code. 16326924 Supplier Invitrogen™ Supplier No. PA578220

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Description

Rabbit Polyclonal Antibody

Positive Control: Jurkat (serum starvation for 15 min), Jurkat (serum starvation for 15 min, then 0.13 μg/mL anti-T-cell receptor antibody (clone 305) treatment for 5 min) Predicted Reactivity: Rat (100%), Pig (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
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Specifications

Antigen Phospho-VAV1 (Tyr174)
Applications Western Blot
Classification Polyclonal
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol, 1% BSA and 0.025% ProClin 300; pH 7
Gene VAV1
Gene Accession No. P15498
Gene Alias oncogene vav; p95; p95vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav guanine nucleotide exchange factor 1; vav oncogene; vav proto-oncogene; VAV1; vav-T
Gene Symbols VAV1
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide surrounding phospho Tyr174 of human VAV1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7409
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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