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Invitrogen™ Phospho-Vimentin (Ser83) Polyclonal Antibody
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Product Code. 17702744
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Quantity:
100 μL
Unit Size:
100µL
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17702744 100 μL 100µL
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Product Code. 17702744 Supplier Invitrogen™ Supplier No. PA5121342

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Description

Rabbit Polyclonal Antibody

Positive test controls include: HeLa, NIH/3T3, C6. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: QDSVD.

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Vimentin (Ser83)
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Vim
Gene Accession No. P08670, P20152, P31000
Gene Alias cb28; class-III intermediate microfilament; CTRCT30; epididymis luminal protein 113; FLJ36605; Hel113; intermediate filament; intermediate filament protein; RP11-124N14.1; similar to vimentin; VIM; VIME; Vimentin; vimentin C-terminus
Gene Symbols Vim
Host Species Rabbit
Immunogen A synthetic phosphorylated peptide around S83 of human VIM (NP_0033712).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22352, 7431, 81818
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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