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  8. PIK-75 hydrochloride, MedChemExpress

PIK-75 hydrochloride, MedChemExpress

Product Code. 16445618
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50 mg
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Product Code. 16445618

Brand: Medchem Express HY13281

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Description

MedChemExpress PIK-75 hydrochloride is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 hydrochloride inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 hydrochloride induces apoptosis.

PIK-75 hydrochloride is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 hydrochloride inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 hydrochloride induces apoptosis.

Specifications

Chemical Name or Material PIK-75 hydrochloride
CAS 372196-77-5
Color White
Purity Grade Notes Research
Molecular Formula C16H15BrClN5O4S
Quantity 10 mg
Solubility Information DMSO : 11 mg/mL (22.51 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES BrC(C=C1)=CN2C1=NC=C2/C=N/N(S(=O)(C3=C(C=CC([N+]([O-])=O)=C3)C)=O)C.[H]Cl
Molecular Weight (g/mol) 488.74
Formula Weight 488.74
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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