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Eurofins DiscoverX PKG1α Protein, Active
Description
In smooth muscle cells, one of the major receptors for cGMP is the serine/threonine protein kinase, cGMP-dependent protein kinase 1, beta isozyme (PRKG1B). PRKG1 has been shown to catalyze the phosphorylation of a number of physiologically relevant proteins whose function it is to regulate the contractile activity of the smooth muscle cell. Two main types of PRKG are present in eukaryotic cells. Type I is widely distributed and is isolated from soluble extracts of tissues, such as cardiac and smooth muscle, as well as lymphoid cells. Type II is a particulate form of the enzyme and has a limited tissue distribution.
GenBank D45864
Specifications
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Molecular Weight (g/mol) | 80 kDa |
| Quantity | 250 μg |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal 6His |
| Expression System | Recombinant enzyme expressed in Sf21 insect cells |
| Protein Form | Full-length |
| Purity or Quality Grade | ≥64% |
| Protein | PKG1α, active |
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